Normal iron content in the body is about 3 to 4 grams. This metal, so important to the proper functioning of the human body is maintained within physiological values due to the balance between what is consumed with the diet and the losses that allows its elimination. Sweat, skin desquamation and menstrual bleeding in women are ways of getting rid of this trace element. Since there is no normal mechanism for the excretion of excess iron once it has been absorbed in the body, iron overload is a condition that should be taken into account in medicine. Regular blood transfusions, so necessary to treat certain conditions, are a common cause of iron overload. For this reason, transfused patients, as well as individuals with hereditary hemochromatosis, present a high risk of suffering from the consequences of excess iron in the body. In this work, we are proposing an updated review of a poorly known condition, as a necessary contribution to your professional activity.