Colorectal Carcinoma Susceptibility and Metastases are Associated with Matrix Metalloproteinase-7 Promoter Polymorphisms (Technical Briefs) - Clinical Chemistry

Colorectal Carcinoma Susceptibility and Metastases are Associated with Matrix Metalloproteinase-7 Promoter Polymorphisms (Technical Briefs)

By Clinical Chemistry

  • Release Date - Published: 2003-11-01
  • Book Genre: Chemistry
  • Author: Clinical Chemistry
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Colorectal Carcinoma Susceptibility and Metastases are Associated with Matrix Metalloproteinase-7 Promoter Polymorphisms (Technical Briefs) Clinical Chemistry read online review & book description:

Tumor invasion and metastasis are important aspects of tumor progression, and the formation of tumor metastasis is a principal contributing factor to cancer morbidity and mortality (1). Basal membrane and extracellular matrix represent two physical barriers to malignant invasion: their degradation by matrix metalloproteinases (MMPs) plays a key role in tumor progression and metastatic spread (2, 3). MMP expression in tumors is regulated in a paracrine manner by growth factors and cytokines secreted by tumor-infiltrating inflammatory cells as well as by tumor or stromal cells. Recent studies have suggested continuous cross-talk between tumor cells, stromal cells, and inflammatory cells during the invasion process (1, 2, 4, 5). Expression of most MMPs is usually low in tissues and is induced when remodeling of extracellular matrix is required. MMP gene expression is primarily regulated at the transcriptional level, but there is also evidence of modulation of mRNA stability in response to growth factor and cytokines (2, 6).

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