Advances in Research and Treatment for Alzheimer’s disease - Samuel Barrack

Advances in Research and Treatment for Alzheimer’s disease

By Samuel Barrack

  • Release Date - Published: 2015-02-26
  • Book Genre: Medical
  • Author: Samuel Barrack
Our rating: 5/5 stars

Score: (From 0 Ratings)

Advances in Research and Treatment for Alzheimer’s disease Samuel Barrack read online review & book description:

Abstract

Background: Dementia drug development aims to modulate pathological processes that cause clinical syndromes. Population data (epidemiological neuropathology) will help to model and predict the potential impact of such therapies on dementia burden in older people. Presently this can only be explored through post mortem findings. We report the attributable risks (ARs) for dementia at death for common age-related degenerative and vascular pathologies, and other factors, in the MRC Cognitive Function and Ageing Study (MRC CFAS).

Methods and Findings: A multi centre, prospective, longitudinal study of older people in the UK was linked to a braindonation programme. Neuropathology of 456 consecutive brain donations assessed degenerative and vascular pathologies.
Logistic regression modelling, with bootstrapping and sensitivity analyses, was used to estimate AR at death for dementiafor specific pathologies and other factors. The main contributors to AR at death for dementia in MRC CFAS were age (18%),small brain (12%), neocortical neuritic plaques (8%) and neurofibrillary tangles (11%), small vessel disease (12%), multiple vascular pathologies (9%), and hippocampal atrophy (10%). Other significant factors include cerebral amyloid angiopathy(7%) and Lewy bodies (3%).

Conclusions: Such AR estimates cannot be derived from the living population; rather they estimate the relative contribution of specific pathologies to dementia at death. We found that multiple pathologies determine the overall burden of dementia.

The impact of therapy targeted to a specific pathology may be profound when the dementia is relatively ‘‘pure,’’ but may beless impressive for the majority with mixed disease, and in terms of the population. These data justify a range of strategies, and combination therapies, to combat the degenerative and vascular determinants of cognitive decline and dementia.

Please see later in the article for the Editors’ Summary.

@2019 – Go Read a Book. All Right Reserved. goreadabook.org is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for website owners, to earn advertising fees by linking and advertising to amazon.com and any other website that may be affiliated with Amazon Service LLC Associates Program; As an Amazon Associate I earn from qualifying purchases.

Advances in Research and Treatment for Alzheimer’s disease book review Advances in Research and Treatment for Alzheimer’s disease ePUB; Samuel Barrack; Medical books.

Post a review about this book